The oral route is an important route for local and systemic drug delivery due to its large surface area, significant porosity, and high blood volume. Orally dissolving films (ODF) have become more popular compared to orally dissolving tablets. ODF is designed to dissolve rapidly upon contact with aqueous surfaces such as oral mucosa. Therefore, enable customers to use the product without needing water. Rapid cracking and breaking is achieved by using appropriate polymers. The polymers used must be non-toxic, non-irritating, odorless and effective. There are two types of polymers used: natural polymers and synthetic polymers. Polymers commonly used in the film industry include “chitosan, guar gum, xanthan gum, soybean polysaccharides, gellan gum, locust bean gum, maltodextrin, and rosin.” Commonly used synthetic materials include “hydroxypropyl cellulose, polyvinylpyrrolidone, hydroxypropyl methylcellulose, polyethylene oxide, and polyvinyl alcohol.” The purpose of this review is to provide a description of the various polymeric materials used in the production of oral films.