Chronic pain and inflammation represent significant challenges in healthcare, necessitating the exploration of innovative therapeutic approaches. This review explores the potential of solid lipid nanoparticles (SLNs) for delivering Vitex negundo oil, an herbal remedy, in managing pain and inflammation. Despite limited prior research, SLNs offer promise in enhancing bioavailability and efficacy. The review outlines mechanistic insights and synergistic effects, proposing future research directions. Key considerations include formulation optimization, safety evaluation, and regulatory pathways for clinical translation, emphasizing the need for further exploration of SLN-based Vitex negundo oil formulations in pain and inflammation management.