For more than 3000 years, Phyllanthus amarus Schum and Thonn herbs have been used in traditional medicine. It belongs to the Euphorbiaceous family and has several names, including “bring me the seed", "stonebreaker", and "wind gala". The term "colon drug delivery system" describes the deliberate administration of medications to the large intestine and other lower digestive tract organs. For the localized treatment of a number of colonic conditions, including colon cancer, IBD, inflammatory bowel disease (such as ulcerative colitis and Crohns disease), drug administration tailored too peculiar regions of the GIT are advantageous. This plant has been used historically as a stomachic, gastro-protective, and appetizer for eons. The plant has been used traditionally for years as a stomachic, gastro-protective, and appetizer. It is commonly recognized that the medication has a gastro-protective effect. The process may involve a reduction in stomach ulcers, suppression of edema, evacuation of leukocytes from submucosal layers, and enhancement of appetite through increased contraction of the gastric mucosa and inhibition of inflammatory cells. It is prepared by tablet formulation by using following ingredients, p. amarus, glycyrrhiza glabra, Microcrystalline cellulose, cross providon, Talc, Magnesium stearate, Starch paste and evaluating by this test, Tablet hardness, Friability test, Dissolution test, disintegration time test. Xanthum gum is used as a polymer. The formulation showed good efficiency and has passed all evaluation parameters.