The development of urinary calculi (stones) in the urinary system, or urolithiasis, is a major global health problem. The plant Senegaliapennata, which is believed to have therapeutic characteristics, has attracted interest due to its possible anti-urolithiatic effects. This study used established procedures to evaluate Senegaliapennata extracts in-vitro anti-urolithiatic efficacy. Senegaliapennata was first used to make organic and aqueous extracts. The effectiveness of the extract in blocking important urolithiasis processes, such as nucleation and aggregation, was then assessed using a series of in-vitro experiments. significant inhibition of crystal formation and growth. Additionally, the extract exhibited notable antioxidant and anti-inflammatory properties, which are crucial in mitigating urolithiasis-associated tissue damage.This study underscores the potential of natural products, particularly plant-derived extracts, as alternative or adjunctive therapies for urolithiasis, offering novel avenues for drug discovery and development in this field.