Curcuma longa is a hydrophobic polyphenol that is produced from its rhizome. Asians often use curcumin as a spice in food and topical medicine to relieve inflammatory ailments. Its potent antiinflammatory and neuroprotective qualities allow it to pass through the blood-brain barrier as well. Because of its wide range of pharmacological effects, curcumin has been suggested as a potential treatment for a number of neurological disorders. Curcumin has pleiotropic properties, but its rapid elimination, low stability, and poor solubility have limited its therapeutic applications. Recent advances in nanotechnology-based drug delivery systems have led to notable improvements in curcumins bioavailability and water solubility. The benefits of employing curcumin nanoparticles and the noteworthy developments in this area of medicine are also covered. There are numerous central nervous system (CNS) illnesses. There is evidence linking curcumin nanoparticle effects and potential mechanisms of action to a number of central nervous system (CNS) diseases, such as Parkinsons, Alzheimers, Huntingtons, multiple sclerosis, epilepsy, and amyotrophic lateral sclerosis.