The synthesis of Schiff bases represents a cornerstone in organic chemistry due to their wide array of applications in medicinal chemistry, material science, and catalysis. This study focuses on the synthesis of a o-vanillin and phenyl urea were the sources of the Schiff base. Utilizing chloroacetic acid as a catalyst. The reaction proceeds through the condensation of o-vanillin, an aromatic aldehyde, and phenyl urea, an amine derivative, under mild conditions. Chloroacetic acid acts as an efficient catalyst, promoting the formation of the imine linkage by facilitating the nucleophilic attack of the amine on the carbonyl group. The use of chloroacetic acid as a catalyst in this synthesis offers a novel approach that enhances reaction efficiency and yields, while operating under relatively mild conditions. This methodology provides a valuable contribution to the field of Schiff base synthesis, offering potential pathways for development new substance containing significant industrial and medicinal uses.