The most common urinary disorder in the world, urolithiasis, is caused by saturated crystals called kidney stones, which is from elements existing in the urine. Stalactites, another name for the phosphoric crystals, is created from infections of the urinary system. Although there are many synthetic medications available, using conventional drugs or botanicals to treat kidney stones has proven to be a promising approach. To explore an anti-lipidoglycan effectiveness among the conventional, Planting: Bitter melon an extract made from water of Piper betle Linn. leaves have been utilized. In the current experiment, the extract of Piper betel leaves was tested using three different types of assays: nucleation, aggregation, and oxalate depletion assays. The primary goals of the research are to assess the in vitro impact on kidney stone disintegration and explore the possibility of Piper betel in the prevention or treatment of kidney stones. The capacity of Piper betles aqueous extract to help dissolve kidney stones has been demonstrated, highlighting the plants potential use as a natural renal stone cure. According to this research, kidney stones may be treated with piper betle as a non-invasive and perhaps affordable alternative to conventional medical procedures.