Pharmacovigilance is the process of monitoring drug interactions and their effects on the human body. It is a vital component of the healthcare system. This page describes the aim of PVPL the aim of pharmacovigilance, the nationwide ADR monitoring centre list, and the uses of these centres. Promoting safe drug use may be given priority by Pharmacopoeia Commission of India, which acts as the national coordinating body for national pharmaceutical services This article defines and describes the GCP Protocol designing for clinical trial, Process of Clinical Trial Application (CTA), Elements of the both specification, Design and conduct, and discusses the importance of good trial practise from the perspective of Indian medical research.