The ongoing search for effective antiviral agents has led to the exploration of various chemical compounds, with pyrimidine derivatives emerging as promising candidates due to their broad- spectrum antiviral activities. This study focuses on the molecular docking of a series of pyrimidine derivatives to evaluate their potential as antiviral agents. Utilizing advanced computational techniques, we performed molecular docking simulations In order to forecast these compounds binding affinities and patterns of interaction with important viral proteins including proteases and polymerases, which are crucial for viral replication. Our findings underscore the significance of pyrimidine derivatives as a scaffold for the development of novel antiviral drugs. The high binding affinities observed in this study warrant further experimental validation and optimization of these compounds. This research not only contributes to the identification of potential antiviral agents but also enhances the understanding of molecular interactions that govern antiviral activity, paving the way for the rational design of more potent antiviral therapeutics.