To improve the therapeutic potential of traditional herbal medicines, there has been a notable upsurge in interest in and development of innovative herbal drug delivery systems (NDDS) in recent years. Herbal medications have long encountered difficulties such low absorption, stability problems, and irregular dosage, despite being widely available and frequently acknowledged for their low side effects. Modern pharmaceutical techniques have been used with herbal formulations to overcome these constraints, leading to the development of sophisticated drug delivery systems that improve the safety and effectiveness of herbal medications. Innovative herbal drug delivery systems enhance the pharmacokinetics and targeted distribution of active herbal ingredients by utilizing technologies such as liposomes, nanoparticles, phytosomes, and microspheres. For example, liposomes and phytosomes have weakly water-soluble herbal compounds bioavailability, and solid lipid nanoparticles sustained release that lowers dosage frequency and adverse effects. These systems can also be customized to target particular tissues or organs, providing an effective and individualized course of treatment. Herbal medications have the potential to significantly help treat a variety of diseases, such as cancer, diabetes, cardiovascular diseases, and neurodegenerative disorders, thanks to developments in NHDDS. To position NHDDS as a trustworthy substitute in contemporary treatments, future research should concentrate on regulatory standardization, formulation process optimization, and clinical translation. The amalgamation of conventional herbal knowledge and contemporary drug delivery systems signifies a propitious avenue for augmenting the medicinal effectiveness of natural items