Fast dissolving tablets, or FDTs, have drawn a lot of attention because of how convenient and simple they are to use. Patients with dysphagia, the elderly, and children can especially benefit from FDTs. In order to improve disintegration and dissolving properties, the objective of this work was to construct and assess FDTs of a model medicine employing a variety of natural super disintegrants. For fast-dissolving formulations, the model drug “Paracetamol” was selected because of its common therapeutic application. The drug-compatibility and disintegration efficiency of a variety of naturally occurring super disintegrants, including Guar gum, Banana powder, Mangifera indica gum, Agar and Arachis hypogaea shell powder. Super disintegrants, other excipients, and the model medication were combined to create the tablets using the wet granulation process. In order to maximize the disintegration duration and dissolution profile, many formulations containing different concentrations of super disintegrants were created. To evaluate factors such weight variation, hardness, friability, disintegration time, and drug release profile, the produced FDTs were evaluated in vitro. The outcomes showed that, in comparison to traditional formulations, the addition of natural super disintegrants greatly shortened the tablets disintegration time. Additionally, dissolving tests showed higher rates of drug release, proving that natural super disintegrants are useful for accelerating medication disintegration. All things considered, the created FDTs showed encouraging traits for quick medication delivery, indicating their possible use in enhancing patient adherence and treatment results.