There is conventional semisolid dosage form in that formulation, optimization & in-vitro evaluation study is carried out. The development of effective and stable dosage form is important for the delivery of therapeutic agent to the skin, in that semisolid dosage form are used like Ointment, Cream, Paste, Gel. In a proper substrate, 1 or more active ingredients are equally shared, were they evaluated for their rheological property, spread ability, viscosity and drug release profile. This study highlighted the need of formulation techniques and in vitro assessments in creating semisolid dosage forms to satisfy clinical requirements and enhance patient acceptance of the product.