The majority of herbal ointments are composed of plant extract odours found in the plants themselves. Nowadays, ointments are mostly utilised as therapies for a variety of skin conditions, including cellulitis, psoriasis, eczema, and herpes. The formulation and assessment of Neem and Turmeric Extract Ointment are the focus of this investigation. Ethanolic extract is made via the maceration process. The ointment was prepared using the levigation method, and its characteristics (physical and chemical)—color, the pH value, accessibility, extrudability, distribution analysis, washability, uniformity, and saturation were assessed by adding the extract as the formulation was finished. Additionally, spreadability and irritability are tested at different temperatures. These extracts have the ability to treat a variety of dermatological conditions when added to ointment compositions. This study compiles the current knowledge on the formulation techniques, phytochemical composition, and assessment criteria of herbal ointments containing turmeric and neem extract. It is employed as a antibacterial, antioxidant, anti-inflammatory, antiseptic, and anti-cancer properties, taking advantage of the benefits from plants.