Recent advancements in TDDS have significantly increased the efficacy and convenience of medicine administration (TDDS). Permeability has been enhanced and release profiles have been regulated thanks to advancements in polymer science, nanotechnology, and microneedle technology. These developments reduce the negative consequences of using conventional administration techniques while enabling the distribution of a greater variety of therapeutic substances, including as proteins, peptides, and small molecules. By using electrical or ultrasonic energy, enhanced formulations like iontophoresis and sonophoresis further increase medication penetration. Moreover, the development of smart transdermal systems combined with sensors for real-time monitoring promises a dramatic leap towards customized treatment. This study highlights the future paths of TDDS in improving clinical practice by discussing these latest advancements, their methods of action, and possible ramifications.