Hydrogels are more sophisticated smart polymers that have a variety of ligands and cross-links that enable highly controlled structures and various bio responsive functions Utilizing swellable multimeric polymers called hydrogels as a drug delivery system has drawn a lot of interest. These unique Properties that have garnered attention include sensitivity to temperature and pH, swelling in an aqueous medium, and sensitivity to various stimuli These are biomaterials. Because they are biocompatible, hydrogels have been shown to exhibit drug-protective properties, specifically for peptides along with proteins from the in vivo setting. These are swelling in polymers, also useful as attainable delivery systems Regarding tissue specific biologically active medications. Furthermore, emphasis is placed on the use of adjuncts such as nanoparticles to enhance the therapeutic benefits of herbal medicines in hydrogel matrices. In general, hydrogels are a flexible medium that can be used to enhance the administration of herbal remedies, encouraging their clinical use and efficacy in contemporary medicine. Traditional medicine includes herbal medicine as a major component that is utilised to treat a variety of illnesses. For numerous years, Asians have used herbal remedies. Nevertheless, plant extracts medicinal value and applicability. Due to their affordability and efficacy in clinical treatment, naturally derived herbal medications with anti-inflammatory qualities are of interest. We present a novel supramolecular hydrogel that consists of a self-assembling natural herb called Rhein, together with an oxidatively responsive cross-linked network that recognizes the actual host-audience relationships in between β-cyclodextrin along with ferrocene. The fact that the review represents the hydrogel as a drug delivery system in herbal medicine.