Antibiotic resistance [AR] is a global health concern, as multidrug-resistant bacteria emerge in hospitals and communities. Antibiotic resistance genes can be found outside of hospitals. Antibiotic resistance is primarily caused by bacterial responses under selective forces. Bacteria use numerous defenses mechanisms to survive, such as chemical modification of an antimicrobial agent, breakdown mediated by enzymes, modified permeability, efflux pump, target site alteration, and biofilm development. Bacteria can develop resistance to commonly used antibiotics. Different pathways can rise in the spread of AR in microbes, making previously vulnerable microorganisms resistant to antibiotics. The overuse of antibiotics by humans is one of several causes that exacerbate the antibiotic resistance dilemma.