Now a days there is huge demand of the herbal products mostly herbal cosmetics which were used by the most of people now a days so there is increasing demand of the herbal products. Acne is the most observed skin problem which can be treated with the herbs the plant of azadrichta Indica leaves can be used in treatment of acne this plant cannot be used directly that can harm to the human skin for that the Herbal formulation of the cream is designed and evaluated. The cream is further evaluated for the safety and stability studying for the effective use in humans. For Indian people neem is very religious plan that having the multipurpose activities like antibacterial, anti-fungal, etc.