The use of natural products in drug development and discovery is increasing. Their chemical diversity allows them to affect multiple targets simultaneously in complex systems. The past decade has seen notable technological advancements in the field of herbal medicine. The traditional foundations of ancient medicine can provide insight into the safety of natural medicines. Now is the time to make decisions about the safety of herbal medicines. The legal status and methods used to approve herbal medicines also vary from country to country. The evaluation standard for effectiveness, safety, and quality of herbal medicines are given by WHO. Advances in science and technology are pervasive in natural medicine products. To keep pace with these developments, numerous review articles have been written on the topic to provide a user-friendly platform for those new to this vast field.