This comprehensive review article delves into the multifaceted realm of Acne Vulgaris, offering a succinct yet informative exploration of its etiology, pathogenesis, clinical presentation, treatment approaches, prevention strategies, and the challenges that persist in its management. Beginning with an introduction defining Acne Vulgaris and elucidating its prevalence and demographic patterns, the review underscores the significance of understanding this common skin condition by delving into its profound impact on quality of life, both socially and psychologically. The article navigates through the intricate web of factors contributing to acne, including genetic predispositions, hormonal influences, and microbial elements, unraveling the pathogenesis of acne lesions from the formation of comedones to the ensuing inflammatory responses. Clinical presentation is elucidated through a discussion of various acne lesions and grading systems, emphasizing the importance of accurate assessment in guiding patient management. Treatment approaches are systematically outlined, encompassing topical and systemic therapies, alongside emerging intervention sand prevention strategies.This review concludes by addressing current issues such as antibiotics and exploring the potential of personalized medicine to shape future pest control. This article is a great resource for doctors, scientists, and anyone who wants to better understand acne vulgaris. The review concludes by addressing current challenges such as drug resistance and exploring the potential of personalized medicine in shaping the future landscape of acne. Acne management. This article is a great resource for doctors, scientists, and anyone who wants to better understand acne vulgaris.