The mouth is home to many diseases. In summary, some oral bacteria are harmless, while others are problematic and can lead to plaque, bad breath, and mouth infections. Thus, maintaining proper dental hygiene is crucial for both physical and oral health. Herbs are essential if you want to distinguish them from pharmaceuticals. Because of their antibacterial and antifungal qualities, medicinal plants have been used for decades to treat human ailments. Herbal products help control plaque, inhibit bacterial growth, freshen breath and clean teeth. Mouthwashes containing herbs can be used in addition to various other oral hygiene procedures (such brushing and flossing). They have the power to fight diseases and prevent plaque, and therefore can be used to support treatment. Many herbs such as neem, turmeric, cloves, mint and their extracts show good medicinal properties. The use of medicinal plants in the treatment of human illnesses has been significant. for many years with their antibacterial, antifungal and antiviral properties. If these arrangements can be made, people can easily prepare and use them at home using natural products. It can improve people overall health. Herbal mouthwashes are in high demand as they treat mouth infections and provide instant relief with little or no side effects. One of the most common diseases that many people face at different stages of their lives is dental disease and gum disease. This review attempts to provide an overview of natural ingredients that can be used as mouthwash. This study aims to develop a multi-antibiotic mouthwash.