This abstract provides a concise overview of the therapeutic potential of papaya (Carica papaya) in human diseases, exploring its impact on digestive health, inflammatory conditions, antioxidant support, immune system modulation, and cancer prevention. The analysis is based on a review of relevant research articles from reputable journals. Papaya (Carica papaya) is a tropical fruit known for its rich nutritional profile, including vitamins, minerals, and enzymes. This essay explores the extensive research on the beneficial activities of papaya in various human diseases. Papaya (Carica papaya) is a tropical fruit renowned for its rich nutritional composition and numerous health benefits. This detailed abstract explores the multifaceted beneficial activities of papaya in various aspects of human health, focusing on its impact on digestion, inflammation, antioxidant defense, immune modulation, and potential in cancer prevention. Papaya (Carica papaya) has gained recognition not only as a delectable tropical fruit but also as a potential powerhouse of health benefits. This comprehensive review delves into the diverse aspects of papaya nutritional profile, bioactive compounds, and their therapeutic implications in human health.