Acne vulgaris is a common pilosebaceous skin condition that primarily affects areas of the face, trunk, and back that have large oil glands. Lesions, come dones, and inflammatory seborrhea are frequently formed as a result of acne. Pus in acne is caused by Propionibacterium acnes and Staphylococcus epidermidis, which in turn causes inflammation. The antibacterial properties of a polyherbal anti-acne cream that contains plant extracts of clove oil, Ocimum sanctum (leaves), and Azardiachata indica (leaves) were extracted through a maceration process using ethanol solvent. The invitro method was utilized to assess the antibacterial potential of the ethanol extract of tulsi and neem leaves, which were used to make an anti-acne cream (like agar cup method) When compared to a single plant extract, the polyherbal cream antibacterial action produced. a larger zone of inhibition (ZI). Consequently, it should be noted that the polyherbal anti-acne cream, which was created with a focus on Propionibacterium, the common bacteria that causes acne, has the potential to have an antibacterial effect in any acne treatment. Many people now prefer to use herbal products over synthetic ones because of the increased side effects of allopathy cream. It is commonly used to treat acne and has additional properties such as anti-aging, anti- inflammatory, and antibacterial properties. Additionally, the prepared polyherbal anti-acne cream met every requirement of the pharmaceutical evaluation. To determine whether a cream is suitable for human skin, certain evaluation tests are carried out. This tests Physical assessment, Spreadability, pH, Viscosity, Homogeneity and Washability test determine whether the cream causes irritation after being applied to the skin or not.