In our lab, we employ specially designed synthetic microwave technology. Chemical or organic chemistry is the process that creates all of these materials. A temperature of 55˂°C must be maintained for 30 minutes during the aspirin derivative production procedure. Microwave treatment yielded production that was comparable, if not better, over a short period of time (7 min at 175 W). The synthesis times for aspirin are reduced to 7 minutes, while the Claisen condensation time is decreased to 4.5 minutes. Compared to a typical effect of 72.08%, aspirin has an 85.88% influence on microwave technology. Microwave-assisted synthesis has several advantages over conventional heating methods, including shorter reaction times, higher yields, and improved product purity. The synthetic para-amino salicylic acid was subjected to a number of spectroscopic and analytical techniques to confirm its purity and molecular structure. The developed synthesis methodology is a helpful tool for the rapid synthesis of 4 Acetamido Salicylic Acid derivatives with potential therapeutic applications.