Senegalia pennata, a medicinal plant known for its various therapeutic properties, was investigated for its potential anthelmintic activity against common intestinal worms. The plant extracts were prepared using different solvents, including water, ethanol, and methanol. The anthelmintic activity was evaluated using in vitro assays with adult worms of parasitic species commonly found in humans. The results demonstrated significant anthelmintic activity of Senegalia pennata extracts, particularly the ethanol and methanol extracts, against a range of intestinal worms such as Ascaris lumbricoides, Trichuris trichiura, and hookworms. The ethanol extract showed the highest efficacy, causing paralysis and death of the worms at relatively low concentrations. Overall, our study provides scientific evidence supporting the traditional use of Senegalia pennata in treating parasitic infections and highlights its potential as a source of natural anthelmintic agents. To clarify the precise mechanisms of action and improve formulations for useful uses in animal and human health, more investigation is necessary.