Herbal medicine has a significant influence on human health and illnesses nowadays. Herbal therapy is significant in many areas, including the medical and financial. Despite this, the use of these herbal remedies is growing daily due to its high caliber, effectiveness, and safety. This study investigates a novel formulation that includes cream (O/W) extracts of Carica papaya, Ficus religiosa, Psidium gujava, and Curcuma longa. The pharmaceutical properties of the formulation, including its pH, viscosity, spreadability, and appearance, were ascertained Beeswax, sorbitol, and the stearyl alcohol, monooleate, liquid paraffin, methyl paraben, and propyl paraben. Herbal medication is seen as safer than allopathic therapy. Allopathic drugs, on the other hand, may have some negative effects. The cream formulation, on the other hand, is significantly superior to other formulations in terms of the tropical absorption and penetration of the active component.