The purpose of this research is to determine the best model through in vitro tests. Ketorolac Tromethamine is NSAIDS drug with a duration of four to six hours (bioavailability: 90%) and Severe stomach upset. Due to these the purpose of this study is to create an oral composition of Ketorolac tromethamine that raising the duration of the drug, treatment efficiency and patient Compliance, and has the ability to overcome intestinal disorders. The ingredients of Ketorolac Tromethamine Sublingual Film include HPMC E15 and HPMC E5. These polymers are Produced using a heavy casting process. Mucoadhesion strength, swelling behavior, surface pH testing, hygroscopicity, water loss, tensile strength, texture, thickness, weight and content integrity. Oral forms (ODFs) have become a simpler, faster and patient-friendly way to deliver Medications. The potent non-steroidal anti-inflammatory drug ketorolac has shown potential to Alleviate postoperative pain. The purpose of that study was to create and assess ketorolac ODF To improve patient compliance and reduce pain. Rapid preparation of antibiotics was attempted in this study to increase patient compliance, Increase treatment efficiency, and reduce gastrointestinal side effects by preventing direct Contact between ketorolac tromethamine and the gastric mucosa. In the present work the ODF is prepared using HPMC E 15 and HPMC E 5 in ratio 1:1, the API used is Ketorolac, the formulation shown excellent drug release profile and passed the evaluation parameters like folding endurance.