Synthetic processes are made more efficient, less harmful solvents are used, greenhouse gases are reduced and waste is eliminated through the use of green chemistry. Sustainability will involve chemical synthesis. Chemical synthesis has been transformed by the use of microwaves. To put it simply, conventional methods only produce small molecules. Many chemists have adopted the use of microwaves for synthesis due to their economic advantages, higher yield rates, and other benefits. Microwaves are being used for both drug discovery and chemical synthesis. The use of paracetamol and its derivatives in microwaves has been initiated by pharmaceutical research to enhance efficiency and reaction kinetics. Recent modifications to the reaction conditions, solvent selection, and optimization of parameters for synthesis of paracetamol derivatives using microwaves are detailed in this abstract The foundation of microwave-assisted organic synthesis (MAOS) is the effective heat transfer made possible by dielectric heating, which in turn depends primarily on the solvents or reagents capacity to absorb microwave radiation. In the last 20 years, there has been a sharp increase in the utilisation of microwave radiation due to its novel and inventive uses in the fields of material sciences, biological processes, organic and peptide synthesis, polymer chemistry, and nanotechnology. The synthesis of several heterocycles by multi-component reactions (MCRs), cross-coupling reactions, C-H activation reactions, insertion reactions, peptide synthesis, and a variety of other reactions is made possible by the recent MW-assisted catalytic processes that are summarised in this chapter.