The exploration of natural anthelmintic agents is crucial due to the growing concern of drug resistance and side effects associated with synthetic anthelmintics. Abrus precatorius, commonly known as Rosary pea, is a plant renowned for its medicinal properties in traditional medicine. This study investigates the anthelmintic activity of the ethanolic extract of Abrus precatorius leaves. The anthelmintic potential was assessed using various in vitro and in vivo methods, focusing on paralysis and death times of helminths, particularly targeting gastrointestinal nematodes. Results indicated significant anthelmintic activity comparable to standard reference drugs. The extracts efficacy is attributed to its rich phytochemical composition, which includes alkaloids, flavonoids, and saponins. The findings suggest that the ethanolic extract of Abrus precatorius leaves holds promise as a natural anthelmintic agent, offering a safer and potentially cost-effective alternative to conventional synthetic drugs. Further research into the isolation and characterization of specific active compounds could have the way for new, effective anthelmintic therapies.