The utilization of natural chemicals has received a lot of attention because of their potential therapeutic effects, as wound healing is a complex process involving various physiological pathways. Tribulus terrestris and curcumin transdermal patches were created and evaluated for use in wound healing applications. Tribulus terrestris, renowned for its antioxidant and anti-inflammatory qualities, was paired with curcumin, a powerful wound healer that possesses antimicrobial and anti-inflammatory qualities. To evaluate the quality of the patches, physicochemical characterization was carried out, which included measurements for thickness, weight variation, and uniform drug content. Assessing the antimicrobial activity against common wound pathogens, skin irritation potential, and penetration profile were all part of the in vitro evaluation process. In the excision animal wound healing model, the patches of Tribulus terrestris and curcumin seemed to work synergistically to reduce inflammation, promote tissue regeneration, and inhibit microbial colonization, which may improve the overall wound healing process. One common method used in pharmaceutical formulation to create patches for drug delivery is the solvent casting method. Using this technique, patches containing extracts of Tribulus terrestris and curcumin were prepared with an eye toward wound healing.