This study objectives are to create and assess topically applied, anti- acne gel made from garlic juice. Techniques: This study used extraction, gel formulations with varying concentrations of carboxymethyl cellulose (CMC), and gel assessment tests to measure the gel ability to inhibit Propionibacterium acnes and to cause skin irritation, viscosity, pH, and organoleptic activity. Long-term inflammation of the pilosebaceous unit caused by acne vulgaris can result in inflammatory lesions, seborrhoea, comedowns, and other conditions. It has been established Propionibacterium acnes and Staphylococcus epidermidis are common pathogens that cause acne. inflammation. The bacteria Staphylococcus aureus contributes to acne inflammation. Because natural remedies are thought to have Less side effects than synthetic, they are more widely accepted. Demand for herbal formulas is increasing on the international scene. The goal of the current study is to create and assess a herbal anti-acne gel that contains an ethanolic extract of Garlic (Allium sativum) and Neem (Azadirachta Indica). Three formulations (F1, F2, and F3) utilising a neem extract, a garlic extract, and a combination of these two were created in order to optimise the herbal anti-acne gel.