Acne, a multifactorial skin disorder affecting individuals globally, presents both physical and psychological challenges.This abstract provides a comprehensive examination of current perspectives, advancements, and general information regarding anti-acne strategies. Traditional treatments, encompassing topical retinoids, antibiotics, and systemic therapies, have laid the foundation for addressing acne. Recent research sheds light on the genetic and molecular aspects of acne, fostering the emergence of precision medicine for personalized interventions. The intricate relationship between the skin microbiome and acne pathogenesis is a focal point of exploration, offering new avenues for microbiome-modulating therapies. Advances in topical formulations, including microencapsulation technologies, promise improved drug delivery and efficacy. Biologics, hormonal therapies, and botanical extracts represent evolving dimensions in acne therapeutics, showcasing diverse mechanisms of action.