In recent years, the development of NDDS has opened up new possibilities for the treatment of multiple diseases. A Review of NDDS explores the different formulations of herbal medicines that are used for different diseases and the innovative DDS that can enhance their efficacy. The article discusses the potential of various herbal medicines, such as Turmeric, Ajwain, Costus igneus, Mentha in treating a range of different diseases like diabetes, cancer, hypertension, fungal infections. So, there are so many advantages of herbal plant which can be used with new dosage form like NDDS which results better efficacy and valid treatments of various disease conditions. Additionally, the review examines the different types of DDS that have be developed to optimize the delivery of these herbal medicines, including Phytosomes, ethosomes, dendrimers, transferosome. The article also discusses Introduction of NDDS and its importance gout advantages and uses considerations in the development of these DDS. In conclusion, this new article provides an overview of the diverse formulations of herbaceous medicines and the innovative DDS that are being developed to improve their therapeutic potential for the treatment of multiple diseases.