A novel drug delivery system is a fresh method of delivering drugs that highlights the shortcomings of the conventional method. Phytosomes outperformed botanical extract in terms of pharmacokinetic and pharmacodynamic reaction. This study aims to confirm the therapeutic effectiveness of a particular plant extract (Cassia fistula) against particular bacterial strains. To investigate its antibacterial qualities against E. coli, S. aureus, Bacillus subtilis, and Bacillus cereus, the methanolic extract of C. fistula (Amaltas) was used at several concentrations, temperatures, and pH levels The current studys findings support the idea that plant extracts have antibacterial properties and demonstrate that using more natural antibacterial agents instead of pharmaceuticals might help lower the rising prevalence of antibiotic resistance. The studys goal is to create a polyherbal phytosome gel utilizing an extract from amaltas (Cassia fistula). Using a soxhlet device and ethanol, the amaltas are extracted. The formulation of phytosomes is examined for in-vitro drug release studies, Particle size and zeta potential measurements, drug content, % yield, and drug entrapment efficiency. Next, add this phytosomal complex to the gels composition. The spreadability, drug content, pH measurement, homogeneity, and rheological analyses are then used to assess the phytosomal gel formulations.