Plasma levels being kept within the therapeutic rangeis made possible by controlled drug delivery systems, which guarantee a of the medication at the absorption location. By doing this, the requirement for repeated administration is decreased in addition to the negative consequences. In contrast to conventional dosage forms, sustained-release (SR) oral medicines provide a clear benefit. To the extent that a single daily dose satisfactorily addresses therapeutic requirements, they maximize the drugs qualities by reducing the frequency of doses. In addition to maximizing medication value and limiting systemic and local side effects, this strategy guarantees uniform plasma concentration. Increased patient compliance is fostered by its ability to cure or control conditions more quickly while utilizing the least amount of medication. The goal of developing controlled drug delivery systems is to solve issues with conventional medication delivery techniques. These devices provide the medication over a predetermined period of time at a predetermined pace, either locally or systemically. With controlled release formulations, fewer daily doses are required. The field of methods for controlled medication distribution have advanced significantly in the past 20 years, from macro- to nano-scale, with the incorporation of intelligent targeted delivery tactics. Drugs can be gradually administered over an extended period of time Using medication delivery systems with modified or regulated release. These systems cover a range of dose forms, such as injectable and implanted alternatives, as well as oral and transdermal ones. While oral administration is often the preferred form of medication administration, certain compounds provide difficulties such as limited bioavailability because of problems with permeability or solubility.