The variety of natural goods originating from fungus, microorganisms, marine species, and terrestrial plants that are utilized to cure various diseases is surveyed in this article. A wide variety of chemicals produced in discovered from various sources to possess several uses within the common biological disciplines, pharmacology, medicine. Vast variety of natural products are importance in medicine have led tore searchers believe that examining natural resources will produce fresh “lead” Mixtures. As is often known, structural analogs with higher pharmacological, Chemical alteration of they may result in increased activity and decreased adverse effects functions of these lead compounds. Substances produced from different natural sources served as foundation to the creation of therapeutically significant drugs against a range of illnesses containing topotecan, vinblastine, vincristine, and taxol, which are significant anticancer medications with broad clinical applications. This paper will examine some powerful related to lead compounds or medications with anti-malarial, anti-bacterial, anti-HIV, and anticancer properties natural products that were mostly identified between 2016 and 2022. Included are bioactive marine compounds with characteristic structures.