Drugs with poor solubility have a major impact on their bioavailability, absorption and therapeutic efficacy, which presents a substantial difficulty in pharmaceutical development. This article offers a thorough analysis of numerous approaches to improving drug solubility, including both traditional and modern methods. Modern developments like nanotechnology and amorphous solid dispersions are presented alongside traditional methods like particle size reduction, solid dispersion and pH adjustment. Pharmaceutical researchers may maximise drug performance, guaranteeing improved patient results and broadening the spectrum of effective medicinal molecules, by utilising these solubility enhancement techniques. This article aims to offer valuable insights into solubility enhancement techniques to guide future research and development efforts.