This review explores the medicinal and therapeutic uses of Selenicereus undatus (dragon fruit), Santalum (sandalwood), and Curcuma longa (turmeric). Selenicereus undatus is known for its antioxidant-rich fruit, which supports digestive health, boosts the immune system, and habits potential anticancer properties. Santalum, widely recognized for its essential oils, been placed into effect to traditional medication because to its anti-inflammatory effects, antiseptic, and sedative effects, beneficial in skin disorders, anxiety, and respiratory conditions. Curcuma longa is renowned for its bioactive compound curcumin, which possesses anti- tumor, anti- inflammatory, and antioxidant benefits, making it valuable in managing arthritis, digestive issues, and chronic diseases. This review highlights the phytochemical composition, traditional uses, and modern therapeutic applications of these plants, emphasizing their significance in integrative medicine and potential for future pharmaceutical development.