Gulvel is a medicinal herb with several important therapeutic properties. Natural products are becoming increasingly and more beneficial in clinical research since, in contrast to medications, they have no known harmful effects. Giloy, also referred to as “Guduchi,” is widely used in the treatment of several illnesses, according to traditional ayurvedic literature. Since the plants active ingredients have been identified and their biological significance in preventing illness has been demonstrated, interest in it has grown on a global scale. In this review, we address our ongoing studies on the plants genetic variety and biological significance of the individual active constituents of the plant in disease targeting. The reviews next goal is to take advantage of the signalling and metabolic pathways that the compounds found in Tinospora affect.