Helminthic infections present an important risk to both humans and animals, particularly in tropical and subtropical regions. Thanks to the long history of anthelmintic plant application, many plant species are used for centuries in order to cure worm diseases in traditional medical systems across the world. The function of anthelmintic plants is examined in this article, with a focus on their historical use and the bioactive phytochemicals that give them their medicinal properties. Alkaloids, flavonoids, saponins, tannins, and terpenoids are a few examples of phytochemicals that have been found to be important components with strong anthelmintic qualities. The methods of action of these chemicals are described; these include the inhibition of energy production, the disruption of parasite metabolism, and the impairment of worms neuromuscular coordination. The also emphasizes the use of herbal anthelmintic herbs, such as Artemisia, Allium sativum, and Azadirachta indica. The review also focusses on herbal anthelmintic plants that have demonstrated noteworthy efficacy in both traditional applications and contemporary pharmacological research, such as Azadirachta indica, Allium sativum, Artemisia absinthium, and Punica granatum. The significance of these plants as possible substitutes for synthetic medications, which are frequently linked to side effects and drug resistance, is highlighted by this review. The article ends by speculating that additional investigation into these folk cures might result in the creation of more durable, safer anthelmintic medications.