Resistant to antibiotic is a severe threat to global health because it allows for treating serious infections more challenging and increases medical expenses. An overuse and abuse within antibiotics causes this complex problem by causing resistant bacterial strains to evolve. Important obstacles include the need for efficient public health policies, the absence of new antibiotic research, and insufficient surveillance systems. In order to address this epidemic, strategies include developing vaccines, funding in research for new treatments, improving antibiotic stewardship, and encouraging international cooperation. Coordination between many sectors is necessary to address antibiotic resistance in order to control antibiotic use effectively and maintain current treatments.