Cubosome are produced nanoparticles with a soft texture that are used to activate lipids. (for example, phytantriol or monoolein) in water. Cubosomes consist of two distinct aqueous channels that are non-intersecting and three dimensions in size, produced by a lipid bilayer. Cubosomes are special properties that enable medications that are amphiphilic, hydrophilic, and liophillic to be accepted.Here, biocompatible and biodegradable excipients like phytantriol or monoolein are employed. Because of their extremely stable cubic form, cubosomes offer better stability, increased drug retention, and more dissolution. As a result, cubosomes that have these added characteristics have a greater acceptance spectrum. Cubosomes have several uses in various fields. These lyotropic cubic liquid crystalline nanoparticles are becoming more and more well-liked as efficient vehicles for enhancing the solubility of many medications. Water, stabilizer, and amphiphillic lipid make up its key ingredients.