Ayurvedic medicine has long used betel leaf, a herb whose strong antioxidant qualities have drawn interest. By examining the phytochemical content, processes, and potential therapeutic uses of betel leaf, this study seeks to compile the body of research on the plant antioxidant properties. According to the review, betel leaf extracts strong antioxidant properties can be related to their high flavonoid, phenolic acid, and alkaloids content. The study evaluated the effects of solvent and variety variation on antioxidant activity and total phenol content by extracting six distinct kinds of betel leaf from different parts of India using five different solvents. To assess antioxidant activity, the following assays were used: DPPH, ABTS, FRAP, and PCL (Photochem Luminescence). Nevertheless, for TPC, DPPH, and all other antioxidant assays, the most feasible extraction medium was 80% ethanol, and then 80% methanol. Lipid peroxidation inhibition, antioxidant enzyme activation, and free radical scavenging are examples of antioxidant processes. We talk about the anti-aging, anti-inflammatory, anti-cancer, neuroprotective and cardiovascular health therapeutic potential of betel leaf antioxidants. This review emphasises the betel leaf promising antioxidant qualities, highlighting its potential as a natural antioxidant agent for controlling and preventing disorders linked to oxidative stress.