The purpose of gastroretentive systems for drug delivery (GRDDS) is to enhance the pharmacotherapy of medications that have a limited window for absorption in the upper digestive tract. This study offers a thorough analysis of several gastroretentive strategies, such as expandable, high-density, mucoadhesive, and floating system. The benefits, drawbacks, and mechanism of stomach retention of each approach are examined in light of stability, patient compliance, and drug release properties. The potential of formulation design innovations, like the use of polymers and developments in biodegradable systems, to improve the effectiveness and regularity of drug release is investigated. The purpose of gastroretentive systems for drug delivery (GRDDS) is to increase the bioavailability of medications that are absorbed mostly in the upper part of the gut by extending the retention of dose forms in the stomach. Drugs with limited availability windows, those that break down in the gastrointestinal tract, or those that are poorly soluble in intestinal pH benefit from these systems. Each type of GRDDS—floating, bioadhesive, swellable, or expandable—uses a different method to guarantee long-term stomach retention. The effectiveness and predictability of GRDDS have been further enhanced by recent developments in formulation technologies, such as fresh polymers and synthetic materials, which make them attractive choices for delivering medications to the upper intestine and stomach. Various gastroretentive strategies, formulation difficulties, pharmacological and formulation factors influencing stomach retention, and the future prospects of GRDDS in clinical applications are all included in this review.